For decades, blown up by bombs, crushed by dynamite, ravaged by magnets, flattened by boulders, trampled by trains, tricked by tunnels, thrown by springs, run over by steamrollers, betrayed by faulty equipment, tormented by bungee cords, ravaged by rockets, stabbed in the back by batsuits, blasted by rocket skates, overturned by unicycles, shaken by earthquake pills, stretched by wild rubber bands, and thrown off every cliff in the southwestern United States, Kelju K. Kojootti finally has enough and decides to strike back.

Teaming up with billboard accident lawyer Kevin Avery (Will Forte), he takes on ACME Inc. - a greedy giant whose products have been behind every disaster Coyote has faced - and Buddy Crane (John Cena), the slippery corporate lawyer who represents the company.